????? : ???? ????? ?????? ???????? ?? ??? ?????? ??????? ??????.??????? ?? ???? ???????: ??????? ?? ???? ??????? ?????????? ???? ???? ????? ???? ?? ????? ??? ????? ?? ???? ??? ????? ??? ?????? ?????? ?? ?????? ?????????? ??? ???? ????? ????? ?? ?????.Misoprostol, when administered to breeding male and woman rats at doses 6.twenty five instances to